What is Multiple Sclerosis?

Multiple Sclerosis is

  • The most common disabling neurological disease of young adults (350,000 in USA)
  • A neurodegenerative autoimmune disorder of the central nervous system (CNS)
  • Diagnosed in twice as many women than men.
  • A disease where approximately 10,000 new cases are diagnosed (US)
  • Comprised of 4 subtypes:
    • RRMS: Relapsing Remitting
    • SPMS: Secondary Progressive
    • PPMS: Primary Progressive
    • PRMS: Progressive Relapsing
  • A disease where periodic episodes (i.e. relapses, exacerbations,) occur with either full recovery or residual accumulating deficit
  • A disease with symptoms such as fatigue, immobility, spasticity, and bladder dysfunction  A disease which is measured via the Kurtzke Disability Status Scale. Also called EDSS (below).

EDSS: Expanded Disability Scale

EDSS_ExpandedDisabilityScale

SOURCE: KURTZKE JF. RATING NUEROLOGIC IMPAIRMENT IN MULTIPLE SCLEROSIS: AND EXPANDED DISABILITY STATUS SCALE (EDSS). NUEROLOGY. 1983: 33:1444-52